27042021 biotech

Genome Stability Regulation and Cancer Genetics Research group of the School of Biotechnology, SMVDU published a research paper in SCI-indexed journal

27042021 biotech

Ms. Monika Pandita and Ms. Heena Shoket, Research scholars, working under the guidance of Dr. Narendra K. Bairwa, Assistant Professor in the School of Biotechnology and Dr. Rakesh Kumar, Assistant Professor in the School of Biotechnology published a research paper in SCI indexed journal “Journal of Biochemical and Molecular Toxicology” (IF 3.606) titled as “Genetic Interaction between Glyoxylate Pathway regulator UCC1 and La-motif encoding SRO9 regulates stress response and Growth rate improvement in Saccharomyces cerevisiae”. The research article can be accessed using the following URL (http://doi.org/10.1002/jbt.22781).

The research work in the laboratory of Dr. Narendra K Bairwa, is focused on understanding of the gene-gene interaction, genome stability regulation and regulation of stress response at cellular level using Yeast ( S. cerevisiae) as model organism. The most of the biological process and pathways are well conserved from single cell eukaryotes Yeast, to complex multicellular organisms such as Humans. The laboratory of Dr. Rakesh Kumar is focused on the understanding of the role of human’s genes in susceptibility to cancer pathogenesis. The published work highlights the role of metabolic regulator UCC1 gene, conserved across fungal kingdom and its interaction with the conserved La motif RNA binding protein encoding gene SRO9 in regulation of stress response.

The fundamental work published has significance in understanding about the fungal virulence, application to industrial fermentation and screening of the small molecules for cancer therapeutics. The co authors, Ms Shreya Wazir, Ms. Aysuhi Rakewal and Mr. Prabhat Kumar also contributed to the study. The laboratory of Dr. Narendra K Bairwa is supported by the grant from DBT, GOI in the form of Ramalingaswami fellowship (BT/RLF/Re‐entry/40/2012), SERB, DST, GOI (EEQ/2017/0000087) and SMVDU, Katra, Reasi. The Head of the School of Biotechnology, Dr. Sharda M. Potukuchi, Associate Professor, Dean of Sciences, Prof. Ashok Sharma, Head, School of Physics and Dean, R&D, Dr. Rakesh Kumar Jha, Associate Prof. appreciated the authors of the study. The Honourable Vice Chancellor Sir, Prof. RK Sinha congratulated the authors of the study and motivated them to continue to carry out in-house fundamental research work.






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